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Article

A structural and functional analysis of Nna1 in Purkinje cell degeneration (pcd) mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2012

Wu Hui-Yuan, Wang Taiyu, Li Leyi, Correia Kristen, Morgan James I

Abstract excerpt

The axotomy-inducible enzyme Nna1 defines a subfamily of M14 metallocarboxypeptidases, and its mutation underlies the Purkinje cell degeneration (pcd) mouse. However, the relationship among its catalytic activity, substrate specificities, and the critical processes of neurodegeneration/axon regeneration is incompletely understood. Here we used a transgenic rescue strategy targeting expression of modified forms of...

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Identifiers

PMID: 22835831
DOI: 10.1096/fj.12-205047
PMCID: PMC3475255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A structural and functional analysis of Nna1 in Purkinje cell degeneration (pcd) mice.PMID 22835831Read ↗

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