Article
In silico pharmacogenetics of warfarin metabolism.
Nature biotechnology - 1 May 2006
Guo Yingying, Weller Paul, Farrell Erin, Cheung Paul, Fitch Bill, Clark Douglas, Wu Shao-yong, Wang Jianmei, Liao Guochun, Zhang Zhaomei, Allard John, Cheng Janet, Nguyen Anh, Jiang Sharon, Shafer Steve, Usuka Jonathan, Masjedizadeh Mohammad, Peltz Gary
Abstract excerpt
Pharmacogenetic approaches can be instrumental for predicting individual differences in response to a therapeutic intervention. Here we used a recently developed murine haplotype-based computational method to identify a genetic factor regulating the metabolism of warfarin, a commonly prescribed anticoagulant with a narrow therapeutic index and a large variation in individual dosing. After quantification of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.