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Article

<i>In silico</i> and <i>in vitro</i> pharmacogenetic analysis in mice

31 Oct 2007

Abstract excerpt

Combining the experimental efficiency of a murine hepatic in vitro drug biotransformation system with in silico genetic analysis produces a model system that can rapidly analyze interindividual differences in drug metabolism. This model system was tested by using two clinically important drugs, testosterone and irinotecan, whose metabolism was previously well characterized. The metabolites produced after these...

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PMID: 17978195
DOI: 10.1073/pnas.0700724104

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