Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.

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Article

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.

Molecular pharmacology - 1 Feb 1993

Kaminsky L S, de Morais S M, Faletto M B, Dunbar D A, Goldstein J A

Abstract excerpt

The regio- and stereoselectivity of warfarin metabolism have been used to assess structure-function relationships of human P4502C subfamily members. Metabolism was investigated using a yeast cDNA expression system in which full length cDNAs for P4502C8, -2C9 (alleles Arg144 Tyr358 Ile359 Gly417 a...

Topics

Alleles
Base Sequence
Cytochrome P-450 Enzyme System
Humans
Hydroxylation
Molecular Sequence Data
Mutagenesis, Site-Directed
Recombinant Proteins
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity
Warfarin

Source

Open in PubMed

Identifiers

PMID: 8429826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8429826-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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