Article
Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins.
Journal of neurobiology - 1 Jul 2006
Schaeffer Véronique, Patte-Mensah Christine, Eckert Anne, Mensah-Nyagan Ayikoe G
Abstract excerpt
Studies performed with animals suggest neurosteroid involvement in neuroprotection. However in humans, the role of neurosteroidogenesis in the regulation of degenerative processes is unknown. To determine whether cellular factors intervening in degenerative mechanisms may interfere with the process of neurosteroidogenesis in humans, we combined pulse-chase experiments with HPLC and continuous flow scintillation...
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