Article
Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study.
Inflammatory bowel diseases - 1 May 2006
Ferraris Alessandro, Torres Barbara, Knafelz Daniela, Barabino Arrigo, Lionetti Paolo, de Angelis Gian Luigi, Iacono Giuseppe, Papadatou Bronislava, D'Amato Giovanna, Di Ciommo Vincenzo, Dallapiccola Bruno, Castro Massimo
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) has been associated with several polymorphisms in genes likely involved in innate immune responses and integrity of epithelial mucosal barrier. A major role in adult Crohn's disease (CD) has been defined for 3 polymorphisms in the CARD15 gene, whereas variants in the SLC22A4, SLC22A5, and DLG5 genes could have a minor contribution to IBD susceptibility. METHODS: We...
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