Estimating the number of rate limiting genomic changes for human breast cancer.

doi:10.1007/s10549-004-5782-y

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Article

Estimating the number of rate limiting genomic changes for human breast cancer.

Breast cancer research and treatment - 1 May 2005

Zhang Xinan, Simon Richard

Abstract excerpt

We used multistage models that incorporate the age dependent dynamics of normal breast tissue, clonal expansion of intermediate cells and mutational events to fit data for the age-specific incidence of breast cancers in the surveillance, epidemiology, and end results (SEER) registry. Our results suggest that two or three rate limiting events occurring at rates characteristic of point mutation rates for normal...

Topics

Adolescent
Adult
Age Distribution
Aged
Breast Neoplasms
Cell Transformation, Neoplastic
Child
Child, Preschool
Female
Genomic Instability
Humans
Incidence
Infant
Infant, Newborn
Middle Aged
Models, Genetic
Mutation
Phenotype

Source

Open in PubMed

Identifiers

PMID: 15868439
DOI: 10.1007/s10549-004-5782-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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