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Article

A mathematical approach predicting the number of events in different tumors.

Pathology oncology research : POR - 1 Jun 2008

Rieker Ralf J, Hoegel Josef, Kern Michael A, Steger Christina, Aulmann Sebastian, Mechtersheimer Gunhild, Schirmacher Peter, Blaeker Hendrik

Abstract excerpt

Supported by different investigations, multi-step models for tumorigenesis have been proposed for epithelial tumors. The age specific incidence of some cancers shows an exponential rise with increasing patient age. Yet, the onset and the slope of incidence curves varies between tumor types. One simple explanation for this disparity is that the number of mutations required for transformation differs in various...

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PMID: 18431691
DOI: 10.1007/s12253-008-9050-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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