Article
Development of handed body asymmetry in mammals.
Ciba Foundation symposium - 1 Jan 1991
Brown N A, McCarthy A, Wolpert L
Abstract excerpt
We have proposed a three step model for the specification of left-right in mammalian embryos. The fundamental assumption is that handedness is imparted by an asymmetrical molecule. Conversion of molecular asymmetry to the cellular level gives a property to one side of the embryo to bias an otherwise random generation of an asymmetrical gradient which can be interpreted by developing organs. Rat embryos, treated...
Topics
- Animals
- Cell Communication
- Chimera
- Chlorides
- Demecolcine
- Dyneins
- Genotype
- Isomerism
- Kartagener Syndrome
- Lithium
- Lithium Chloride
- Mammals
- Methoxamine