Article
Association study of six activity SNPS in adrenal steroid hormone metabolism and IBM related genes with precocious puberty in Chinese girls.
Neuro endocrinology letters - 1 Jan 2000
Xin Xiujuan, Xiao Junhua, Luan Xiaohui, Zhou Yuxun, Lu Daru, Wei Dongzhi, Yang Shengli
Abstract excerpt
OBJECTIVES: In order to investigate whether the variances in the candidate genes (Insulin receptor substrate IRS-1, beta3-adrenergic receptor ADRB3, 3 beta-hydro-xysteroid dehydrogenase HSD3B2, glucocorticoid receptor GRL and 21-hydroxylase CYP21) which affect the metabolism of adrenal steroids hormone and body composition, are associated with precocious puberty in Chinese girls. METHODS: PCR-RFLP analysis method...
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