Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of POR, SULT2A1 and HSD11B1 in children with premature adrenarche.

Metabolism: clinical and experimental - 1 Sept 2012

Utriainen Pauliina, Laakso Saila, Jääskeläinen Jarmo, Voutilainen Raimo

Abstract excerpt

Premature adrenarche (PA) refers to an earlier than normal increase in adrenocortical androgen production. The pathogenesis of PA remains largely unknown. We hypothesized that common polymorphisms at P450 oxidoreductase (POR), steroid sulfotransferase (SULT2A1), or 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) genes could contribute to the polygenic pathogenesis of PA. We performed a case-control study on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Case-Control Studies
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Finland

Share to Sex Hormone-Binding Globulin

Share to Sulfotransferases

Share to White People

Source

Identifiers

PMID: 22445027
DOI: 10.1016/j.metabol.2012.02.008

Genes

POR
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of POR, SULT2A1 and HSD11B1 in children with premature adrenarche.PMID 22445027Read ↗

Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.Semantic proximity Read ↗

Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome.Semantic proximity Read ↗

A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio.Semantic proximity Read ↗

Congenital lipoid adrenal hyperplasiaSemantic proximity Read ↗

Hypospadias and variants in genes related to sex hormone biosynthesis and metabolism.Semantic proximity Read ↗

Phenotypic variations in lipoid congenital adrenal hyperplasia.Semantic proximity Read ↗

Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria.Semantic proximity Read ↗

Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States.Semantic proximity Read ↗

Cytochrome P450 oxidoreductase deficiency: rare congenital disorder leading to skeletal malformations and steroidogenic defects.Semantic proximity Read ↗

Monogenic and polygenic models detected in steroid 21-hydroxylase deficiency-related paediatric hyperandrogenism.Semantic proximity Read ↗

Relationship between polymorphisms in the sulfotransferase SULT2A1 gene and dehydroepiandrosterone sulfate concentration in children.Semantic proximity Read ↗

Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.