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Article

MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions.

The Journal of biological chemistry - 23 May 2003

Mishra Sandip K, Mazumdar Abhijit, Vadlamudi Ratna K, Li Feng, Wang Rui-An, Yu Wei, Jordan V Craig, Santen Richard J, Kumar Rakesh

Abstract excerpt

The transcriptional activity of estrogen receptor-alpha (ER-alpha) is modified by coactivators, corepressors, and chromatin remodeling complexes. We have previously shown that the metastasis-associated protein-1 (MTA1), a component of histone deacetylase and nucleosome remodeling complexes, represses ER-driven transcription by recruiting histone deacetylases to the estrogen receptor element (ERE)-containing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Mammary Glands, Animal

Share to Proto-Oncogene Proteins c-myc

Share to Receptors, Estrogen

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Source

Identifiers

PMID: 12639951
DOI: 10.1074/jbc.M301968200

Genes

MTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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