Article
The steroidogenic effect of single-chain bovine LH analogs in cultured bovine follicular cells.
Molecular and cellular endocrinology - 27 Jun 2006
Braw-Tal Ruth, Pen Svetlana, Grinberg Moran, Nakav Sigal, Ben-Menahem David
Abstract excerpt
Single-chain gonadotropin analogs had been constructed for the purpose of structure-function studies and analog design. Incorporation of a spacer derived from the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit between the tethered subunit domains of the human gonadotropins is beneficial for the secretion of the single-chain variants without compromising biocactivity. Although the...
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