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Article

Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B.

Journal of virology - 1 May 2006

Shogan Benjamin, Kruse Lori, Mulamba Gilbert B, Hu André, Coen Donald M

Abstract excerpt

We have investigated the antiviral mechanism of a phosphorothioate oligonucleotide, ISIS 5652, which has activity against herpes simplex virus (HSV) in the low micromolar range in plaque reduction assays. We isolated a mutant that is resistant to this compound. Marker rescue and sequencing experiments showed that resistance was due to at least one of three mutations in the UL27 gene which result in amino acid...

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Identifiers

PMID: 16641267
DOI: 10.1128/JVI.80.10.4740-4747.2006
PMCID: PMC1472053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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