Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88.

Virology - 25 Oct 2007

Ekblad Maria, Adamiak Beata, Bergefall Kicki, Nenonen Hannah, Roth Anette, Bergstrom Tomas, Ferro Vito, Trybala Edward

Abstract excerpt

Herpes simplex virus type 1 variants selected by virus propagation in cultured cells in the presence of the sulfated oligosaccharide PI-88 were analyzed. Many of these variants were substantially resistant to the presence of PI-88 during their initial infection of cells and/or their cell-to-cell spread. Nucleotide sequence analysis revealed that the deletion of amino acids 33-116 of gC but not lack of gC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Amino Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Drug Resistance, Microbial

Share to Herpesvirus 1, Human

Share to Oligosaccharides

Share to Tumor Cells, Cultured

Share to Viral Envelope Proteins

Source

Identifiers

PMID: 17604805
DOI: 10.1016/j.virol.2007.05.040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88.PMID 17604805Read ↗

Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity.Semantic proximity Read ↗

Partial resistance to gD-mediated interference conferred by mutations affecting herpes simplex virus type 1 gC and gK.Semantic proximity Read ↗

Mutations in the conserved carboxy-terminal hydrophobic region of glycoprotein gB affect infectivity of herpes simplex virus.Semantic proximity Read ↗

Immune evasion properties of herpes simplex virus type 1 glycoprotein gC.Semantic proximity Read ↗

Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates.Semantic proximity Read ↗

Human immunodeficiency virus type 1 infection of SK-N-MC cells: domains of gp120 involved in entry into a CD4-negative, galactosyl ceramide/3' sulfo-galactosyl ceramide-positive cell line.Semantic proximity Read ↗

Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B.Semantic proximity Read ↗

Tyrosine 116 of the herpes simplex virus type 1 IEalpha22 protein is an ocular virulence determinant and potential phosphorylation site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.