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Article

The crystal structure of Aquifex aeolicus prephenate dehydrogenase reveals the mode of tyrosine inhibition.

The Journal of biological chemistry - 8 May 2009

Sun Warren, Shahinas Dea, Bonvin Julie, Hou Wenjuan, Kimber Matthew S, Turnbull Joanne, Christendat Dinesh

Abstract excerpt

TyrA proteins belong to a family of dehydrogenases that are dedicated to l-tyrosine biosynthesis. The three TyrA subclasses are distinguished by their substrate specificities, namely the prephenate dehydrogenases, the arogenate dehydrogenases, and the cyclohexadienyl dehydrogenases, which utilize prephenate, l-arogenate, or both substrates, respectively. The molecular mechanism responsible for TyrA substrate...

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Identifiers

PMID: 19279014
DOI: 10.1074/jbc.M806272200
PMCID: PMC2676054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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