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Article

Quantitative chimeric analysis of six specificity determinants that differentiate Escherichia coli aspartate from tyrosine aminotransferase.

Protein science : a publication of the Protein Society - 1 Dec 2002

Shaffer Wendy A, Luong Tinh N, Rothman Steven C, Kirsch Jack F

Abstract excerpt

The six mutations, referred to as the Hex mutations, that together have been shown to convert Escherichia coli aspartate aminotransferase (AATase) specificity to be substantially like that of E. coli tyrosine aminotransferase (TATase) are dissected into two groups, (T109S/N297S) and (V39L/K41Y/T47I/N69L). The letters on the left and right of the numbers designate AATase and TATase residues, respectively. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12441383
DOI: 10.1110/ps.0221902
PMCID: PMC2373746

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Source receipt: pubmed, retrieved 7 Sept 2026.

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