Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.

Journal of medicinal chemistry - 4 May 2006

Gao Zhan-Guo, Duong Heng T, Sonina Tatiana, Kim Soo-Kyung, Van Rompaey Philippe, Van Calenbergh Serge, Mamedova Liaman, Kim Hea Ok, Kim Myong Jung, Kim Ae Yil, Liang Bruce T, Jeong Lak Shin, Jacobson Kenneth A

Abstract excerpt

An alternative approach to overcome the inherent lack of specificity of conventional agonist therapy can be the reengineering of the GPCRs and their agonists. A reengineered receptor (neoceptor) could be selectively activated by a modified agonist, but not by the endogenous agonist. Assisted by rhodopsin-based molecular modeling, we pinpointed mutations of the A(3) adenosine receptor (AR) for selective affinity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetinae

Share to Genetic Engineering

Share to Ligands

Share to Myocardial Reperfusion Injury

Share to Nucleosides

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 16640329
DOI: 10.1021/jm050968b
PMCID: PMC3471142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.PMID 16640329Read ↗

Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.Semantic proximity Read ↗

Synthesis of 3'-ureidoadenosines and their high binding affinity at the mutant A3 adenosine receptor.Semantic proximity Read ↗

Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine.Semantic proximity Read ↗

Off-target-free chemogenetic platform that decodes physiological roles of target GPCRsSemantic proximity Read ↗

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.Semantic proximity Read ↗

A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine.Semantic proximity Read ↗

Molecular dissection of the human A3 adenosine receptor coupling with β-arrestin2.Semantic proximity Read ↗

Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling.Semantic proximity Read ↗

Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.Semantic proximity Read ↗

Cancer-Associated Mutations of the Adenosine A2A Receptor Have Diverse Influences on Ligand Binding and Receptor Functions.Semantic proximity Read ↗

Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor.Semantic proximity Read ↗

Functional Expression of Adenosine A3 Receptor in Yeast Utilizing a Chimera with the A2AR C-Terminus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.