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Article

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Journal of medicinal chemistry - 26 Sept 2002

Gao Zhan-Guo, Kim Soo-Kyung, Biadatti Thibaud, Chen Wangzhong, Lee Kyeong, Barak Dov, Kim Seong Gon, Johnson Carl R, Jacobson Kenneth A

Abstract excerpt

Mutagenesis of the human A(3) adenosine receptor (AR) suggested that certain amino acid residues contributed differently to ligand binding and activation processes. Here we demonstrated that various adenosine modifications, including adenine substitution and ribose ring constraints, also contributed differentially to these processes. The ligand effects on cyclic AMP production in intact CHO cells expressing the...

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Source

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Identifiers

PMID: 12238926
DOI: 10.1021/jm020211+
PMCID: PMC9194716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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