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Article

Synthesis of 3'-ureidoadenosines and their high binding affinity at the mutant A3 adenosine receptor.

Nucleic acids symposium series (2004) - 1 Jan 2005

Kim Ae Yil, Kim Hea Ok, Kim Myoung Jung, Chun Moon Woo, Lee Kang Man, Jacobson Kenneth A, Jeong Lak Shin

Abstract excerpt

For the purpose of developing optimal neoceptor-neoagonist pair, 3'-ureidoadenosine derivatives were synthesized. Among compounds tested, 2-chloro-3'-ureido-N6-(3-iodobenzyl)adenosine (10b) showed the best binding affinity (Ki = 0.20 microM) at the H272E mutant A3 AR, but was inactive at the natural A3 AR.

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PMID: 17150655
DOI: 10.1093/nass/49.1.105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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