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Article

Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor.

Molecular pharmacology - 1 May 2003

Gao Zhan-Guo, Kim Soo-Kyung, Gross Ariel S, Chen Aishe, Blaustein Joshua B, Jacobson Kenneth A

Abstract excerpt

We examined the effects on allosteric modulation and ligand binding of the mutation of amino acid residues of the human A(3) adenosine receptor (A(3)AR) that are hypothesized to be near one of three loci: the putative sodium binding site, the putative ligand binding site, and the DRY motif in transmembrane helical domain 3. The effects of three heterocyclic allosteric modulators [the imidazoquinoline...

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Identifiers

PMID: 12695530
DOI: 10.1124/mol.63.5.1021
PMCID: PMC4367541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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