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Article

Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area.

Epilepsy research - 1 Oct 2008

Idro Richard, Williams Thomas N, Gwer Samson, Uyoga Sophie, Macharia Alex, Opi Herbert, Atkinson Sarah, Maitland Kathryn, Kager Piet A, Kwiatkowski Dominic, Neville Brian G R, Newton Charles R J C

Abstract excerpt

Polymorphisms of the haptoglobin (HP) gene and deletions in alpha-globin gene (alpha-thalassaemia) are common in malaria-endemic Africa. The same region also has high incidence rates for childhood acute seizures. The haptoglobin HP2-2 genotype has been associated with idiopathic generalized epilepsies and altered iron metabolism in children with alpha-thalassaemia can potentially interfere with neurotransmission...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18554871
DOI: 10.1016/j.eplepsyres.2008.04.021
PMCID: PMC2670977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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