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Article

The voltage dependence of recovery from use-dependent block by QX-222 separates mechanisms for drug egress in the cardiac sodium channel.

Biochemical pharmacology - 28 Apr 2006

Lardin Harvey A, Lee Peter J

Abstract excerpt

In neuronal sodium channels of squid giant axons, recovery from QX-222 block is slowed by hyperpolarization. However, in ventricular cells, hyperpolarization speeds recovery. Previously, we showed that isoform-specific residues in the external side of the cardiac sodium channel isoform (D1P-loop C373 and D4S6 T1752) influence use-dependent block (UDB) by lidocaine. To determine whether these isoformspecific...

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PMID: 16637111
DOI: 10.1016/j.bcp.2006.01.010

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