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Antimitotic Sulfonamides Inhibit Microtubule Assembly Dynamics and Cancer Cell Proliferation

7 Apr 2006

Abstract excerpt

Several sulfonamides have antitumor activities and are currently undergoing clinical evaluation for the treatment of cancer. In this study, we have elucidated the antiproliferative mechanism of action of five indole sulfonamides. The indole sulfonamides inhibited the polymerization of microtubule protein into microtubules in vitro. In addition, three representative derivatives, ER-68378 (2), ER-68384 (4) and...

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PMID: 16634625
DOI: 10.1021/bi0523409

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