Article
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
Blood - 1 Jan 2004
Takagi Masatoshi, Tsuchida Rika, Oguchi Kaoru, Shigeta Teruko, Nakada Shinichiro, Shimizu Kimiko, Ohki Misao, Delia Domenico, Chessa Luciana, Taya Yoichi, Nakanishi Makoto, Tsunematsu Yukiko, Bessho Fumio, Isoyama Keiichi, Hayashi Yoshiki, Kudo Kazuko, Okamura Jun, Mizutani Shuki
Abstract excerpt
There are conflicting reports about the involvement of single nucleotide polymorphisms (SNPs) of the ataxia telangiectasia mutated (ATM) gene with cancer, and the consequences of these SNPs for ATM function remain unclear. We therefore sought to identify SNPs of the ATM gene in pediatric Hodgkin disease (HD) and to analyze ATM function in cells from patients with these SNPs. We have identified SNPs of the ATM...
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