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Article

A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer.

European journal of cancer (Oxford, England : 1990) - 1 May 2006

Ribeiro Ricardo, Araújo Ana Paula, Coelho Ana, Catarino Raquel, Pinto Daniela, Araújo António, Calçada Carmen, Lopes Carlos, Medeiros Rui

Abstract excerpt

Leptin hormone and receptor have been associated to cancer development and were identified in lung tissue. In this study, a functional polymorphism in the 5' flanking region of the leptin gene (LEP -2548 G/A) was found to increase susceptibility for non-small cell lung cancer [odds ratio (OR), 1.97; 95% confidence interval (CI), 1.13-3.43]. Age-adjusted logistic regression analysis in men indicated an association...

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Source

Identifiers

PMID: 16630717
DOI: 10.1016/j.ejca.2006.02.004

Genes

LEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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