Article
Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia.
Biochemical and biophysical research communications - 2 Jun 2006
Moon Ho Jin, Yim Sung-Vin, Lee Woon Kyu, Jeon Yang-Whan, Kim Young Hoon, Ko Young Jin, Lee Kwang-Soo, Lee Kweon-Haeng, Han Sang-Ick, Rha Hyoung Kyun
Abstract excerpt
Chromosomal abnormalities are implicated as important markers for the pathogenesis in patients with schizophrenia. In this study, with using bacterial artificial chromosome (BAC) array-based comparative genomic hybridization (CGH), we analyzed DNA copy-number changes among 30 patients with schizophrenia. The most frequent changes were partial gain of Xq23 (52%) and loss of 3q13.12 (32%). Other frequent gains were...
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