Article
DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling.
Human molecular genetics - 1 Mar 2006
Wilson Gary M, Flibotte Stephane, Chopra Vikramjit, Melnyk Brianna L, Honer William G, Holt Robert A
Abstract excerpt
Using bacterial artificial chromosome (BAC) array comparative genome hybridization (aCGH) at approximately 1.4 Mbp resolution, we screened post-mortem brain DNA from bipolar disorder cases, schizophrenia cases and control individuals (n=35 each) for DNA copy-number aberrations. DNA copy number is a largely unexplored source of human genetic variation that may contribute risk for complex disease. We report...
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