Article
Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection.
Journal of medical virology - 1 Jun 2006
Shibata Yukiko, Hoshino Yo, Hara Shinya, Yagasaki Hiroshi, Kojima Seiji, Nishiyama Yukihiro, Morishima Tsuneo, Kimura Hiroshi
Abstract excerpt
Chronic active Epstein-Barr virus (EBV) infection is a severe systemic disease associated with high rates of mortality and morbidity. Recent studies suggest that the clonal expansion of EBV-infected T or natural killer cells plays a crucial role in the pathogenesis of chronic active EBV infection. However, it is not clear whether chronic active EBV infection is truly a monoclonal disorder that originates from one...
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