Article
Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2011
Ohga Shouichi, Ishimura Masataka, Yoshimoto Goichi, Miyamoto Toshihiro, Takada Hidetoshi, Tanaka Tamami, Ohshima Koichi, Ogawa Yoshiyasu, Imadome Ken-Ichi, Abe Yasunobu, Akashi Koichi, Hara Toshiro
Abstract excerpt
BACKGROUND: In Japan, chronic active Epstein-Barr virus infection (CAEBV) may manifest with infection of T-cells or NK-cells, clonal lymphoid proliferations, and overt lymphoid malignancy. These EBV-positive lymphoproliferative disorders (EBV(+)LPD) of childhood are related to, but distinct from the infectious mononucleosis-like CAEBV seen in Western populations. The clonal nature of viral infection within...
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