Article
Ultrasensitive monitoring of HIV-1 viral load by a low-cost real-time reverse transcription-PCR assay with internal control for the 5' long terminal repeat domain.
Clinical chemistry - 1 Jul 2006
Drosten Christian, Panning Marcus, Drexler Jan Felix, Hänsel Florian, Pedroso Celia, Yeats Jane, de Souza Luna Luciano Kleber, Samuel Matthew, Liedigk Britta, Lippert Ute, Stürmer Martin, Doerr Hans Wilhelm, Brites Carlos, Preiser Wolfgang
Abstract excerpt
BACKGROUND: Current HIV-1 viral-load assays are too expensive for resource-limited settings. In some countries, monitoring of antiretroviral therapy is now more expensive than treatment itself. In addition, some commercial assays have shown shortcomings in quantifying rare genotypes. METHODS: We evaluated real-time reverse transcription-PCR with internal control targeting the conserved long terminal repeat (LTR)...
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