In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib.

doi:10.1042/BJ20051962

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Article

In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib.

The Biochemical journal - 1 Aug 2006

Sakai Kazuko, Yokote Hideyuki, Murakami-Murofushi Kimiko, Tamura Tomohide, Saijo Nagahiro, Nishio Kazuto

Abstract excerpt

The existence of an in-frame deletion mutant correlates with the sensitivity of lung cancers to EGFR (epidermal growth factor receptor)-targeted tyrosine kinase inhibitors. We reported previously that the in-frame 15-bp deletional mutation (delE746-A750 type deletion) was constitutively active in...

Topics

Antineoplastic Agents
Cell Line
ErbB Receptors
Gefitinib
Humans
Kinetics
Mutation
Phosphorylation
Quinazolines
Sequence Deletion

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