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Article

In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib.

The Biochemical journal - 1 Aug 2006

Sakai Kazuko, Yokote Hideyuki, Murakami-Murofushi Kimiko, Tamura Tomohide, Saijo Nagahiro, Nishio Kazuto

Abstract excerpt

The existence of an in-frame deletion mutant correlates with the sensitivity of lung cancers to EGFR (epidermal growth factor receptor)-targeted tyrosine kinase inhibitors. We reported previously that the in-frame 15-bp deletional mutation (delE746-A750 type deletion) was constitutively active in cells. Kinetic parameters are important for characterizing an enzyme; however, it remains unclear whether the kinetic...

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Identifiers

PMID: 16623663
DOI: 10.1042/BJ20051962
PMCID: PMC1533307

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib.PMID 16623663Read ↗

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Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.Semantic proximity Read ↗

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis.Semantic proximity Read ↗

Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.Semantic proximity Read ↗

Activation mechanism of solubilized epidermal growth factor receptor tyrosine kinase.Semantic proximity Read ↗

Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.Semantic proximity Read ↗

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