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Article

EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy.

Oncogene - 23 Aug 2007

Irmer D, Funk J O, Blaukat A

Abstract excerpt

In 2004 remarkable clinical responses in non-small-cell lung cancer (NSCLC) patients treated with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib were reported to correlate with the presence of certain somatic EGFR kinase domain mutations in tumors. Since then, a surge of enthusiasm has been encountered in the field of molecular and clinical oncology. Beyond the promise of a...

Topics

Animals
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Gefitinib
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
Mutation
Protein Kinase Inhibitors
Protein Structure, Tertiary

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Quinazolines

Source

Identifiers

PMID: 17353898
DOI: 10.1038/sj.onc.1210383

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17353898-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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