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Article

EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy.

Oncogene - 23 Aug 2007

Irmer D, Funk J O, Blaukat A

Abstract excerpt

In 2004 remarkable clinical responses in non-small-cell lung cancer (NSCLC) patients treated with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib were reported to correlate with the presence of certain somatic EGFR kinase domain mutations in tumors. Since then, a surge of enthusiasm has been encountered in the field of molecular and clinical oncology. Beyond the promise of a...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 17353898
DOI: 10.1038/sj.onc.1210383

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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