Article
Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation.
Molecular genetics and metabolism - 1 Nov 2006
Corbo Rosa Maria, Prévost Martine, Raussens Vincent, Gambina Giuseppe, Moretto Giuseppe, Scacchi Renato
Abstract excerpt
Apolipoprotein E (APOE) is an important gene whose common polymorphism, and precisely the e *4 allele, has been reportedly associated with some disorders, including Alzheimer's disease (AD) and coronary artery disease. In the course of previous surveys on AD patients and healthy individuals some rare variants were detected by means of Isoelectric focusing and denaturing high-performance liquid chromatography...
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