Article
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
Diabetes - 1 Jul 2018
van Zuydam Natalie R, Ahlqvist Emma, Sandholm Niina, Deshmukh Harshal, Rayner N William, Abdalla Moustafa, Ladenvall Claes, Ziemek Daniel, Fauman Eric, Robertson Neil R, McKeigue Paul M, Valo Erkka, Forsblom Carol, Harjutsalo Valma, Perna Annalisa, Rurali Erica, Marcovecchio M Loredana, Igo Robert P, Salem Rany M, Perico Norberto, Lajer Maria, Käräjämäki Annemari, Imamura Minako, Kubo Michiaki, Takahashi Atsushi, Sim Xueling, Liu Jianjun, van Dam Rob M, Jiang Guozhi, Tam Claudia H T, Luk Andrea O Y, Lee Heung Man, Lim Cadmon K P, Szeto Cheuk Chun, So Wing Yee, Chan Juliana C N, Ang Su Fen, Dorajoo Rajkumar, Wang Ling, Clara Tan Si Hua, McKnight Amy-Jayne, Duffy Seamus, Pezzolesi Marcus G, Marre Michel, Gyorgy Beata, Hadjadj Samy, Hiraki Linda T, Ahluwalia Tarunveer S, Almgren Peter, Schulz Christina-Alexandra, Orho-Melander Marju, Linneberg Allan, Christensen Cramer, Witte Daniel R, Grarup Niels, Brandslund Ivan, Melander Olle, Paterson Andrew D, Tregouet David, Maxwell Alexander P, Lim Su Chi, Ma Ronald C W, Tai E Shyong, Maeda Shiro, Lyssenko Valeriya, Tuomi Tiinamaija, Krolewski Andrzej S, Rich Stephen S, Hirschhorn Joel N, Florez Jose C, Dunger David, Pedersen Oluf, Hansen Torben, Rossing Peter, Remuzzi Giuseppe, Brosnan Mary Julia, Palmer Colin N A, Groop Per-Henrik, Colhoun Helen M, Groop Leif C, McCarthy Mark I
Abstract excerpt
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D...
Read the complete abstract on PubMed