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Article

RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma.

International journal of cancer - 15 Sept 2006

Kang Sokbom, Lee Jae Myun, Jeon Eun-Sook, Lee Sun, Kim Hogeun, Kim Hy-Sook, Seo Sang-Soo, Park Sang-Yoon, Sidransky David, Dong Seung Myung

Abstract excerpt

Both hypermethylation of the tumor suppressor gene RASSF1A and activating mutations of the KRAS and/or BRAF gene have been reported in a variety of human cancers. To investigate these epigenetic and genetic alterations in endometrial carcinoma (EC), we examined their frequency in 4 uterine EC cell lines and in 75 sporadic primary ECs. Using methylation specific PCR, we found RASSF1A methylation in 25 of 75...

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Share to DNA Methylation
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Microsatellite Repeats

Share to Neoplasm Proteins

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 16619251
DOI: 10.1002/ijc.21991

Genes

KRAS
BRAF

Provenance

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