Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.

Nature immunology - 1 Jan 2009

Sriskantharajah Srividya, Belich Monica P, Papoutsopoulou Stamatia, Janzen Julia, Tybulewicz Victor, Seddon Benedict, Ley Steven C

Abstract excerpt

To investigate the importance of proteolysis of NF-kappaB1 p105 induced by the kinase IKK in activation of the transcription factor NF-kappaB, we generated 'Nfkb1(SSAA/SSAA)' mice, in which the IKK-target serine residues of p105 were substituted with alanine. Nfkb1(SSAA/SSAA) mice had far fewer CD4+ regulatory and memory T cells because of cell-autonomous defects. These T cell subtypes require activation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to I-kappa B Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Lymphocyte Activation

Share to NF-kappa B p50 Subunit

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 19060899
DOI: 10.1038/ni.1685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.PMID 19060899Read ↗

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.Semantic proximity Read ↗

NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic InflammationSemantic proximity Read ↗

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.Semantic proximity Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

Critical role of RelB serine 368 for dimerization and p100 stabilization.Semantic proximity Read ↗

Characterization of ES cells deficient for the p105 precursor (NF-kappa B1): role of p50 NLS.Semantic proximity Read ↗

Enhanced apoptosis of B and T lymphocytes in TAFII105 dominant-negative transgenic mice is linked to nuclear factor-kappa B.Semantic proximity Read ↗

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and DestructionSemantic proximity Read ↗

beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.Semantic proximity Read ↗

The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner.Semantic proximity Read ↗

B cells lacking RP105, a novel B cell antigen, in systemic lupus erythematosus.Semantic proximity Read ↗

Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.