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Article

Domains involved in ETO and human N-CoR interaction and ETO transcription repression.

Leukemia research - 1 Apr 2004

Wang Jianxiang, Wang Min, Liu Johnson M

Abstract excerpt

The (8;21) translocation between the AML1 and ETO genes is seen in approximately 12-15% of all acute myeloid leukemia (AML) and is a frequently observed nonrandom genetic alteration associated with AML. The ETO moiety was shown to interact with the nuclear receptor co-repressor (N-CoR) complex, which includes mSin3A and the histone deacetylase, HDAC1. Repression of AML1-responsive hematopoietic genes by AML1-ETO...

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Source

Identifiers

PMID: 15109542
DOI: 10.1016/j.leukres.2003.08.016

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Domains involved in ETO and human N-CoR interaction and ETO transcription repression.PMID 15109542Read ↗

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complexSemantic proximity Read ↗

The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.Semantic proximity Read ↗

Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesisSemantic proximity Read ↗

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t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming.Semantic proximity Read ↗

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.Semantic proximity Read ↗

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoproteinSemantic proximity Read ↗

RUNX1-ETO: Attacking the Epigenome for Genomic Instable LeukemiaSemantic proximity Read ↗

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesisSemantic proximity Read ↗

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Semantic proximity Read ↗

The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic DifferentiationSemantic proximity Read ↗

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