Article
Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells.
Cancer research - 15 May 2002
Hug Bruce A, Lee Samuel Y D, Kinsler Erron L, Zhang Jinsong, Lazar Mitchell A
Abstract excerpt
AML1-ETO is an oncoprotein that can promote self-renewal of primary hematopoietic cells by opposing the activity of AML1. Two domains, Nervy-homology(NH) 2 and NH4, have been implicated in the recruitment of corepressors by AML1-ETO, but the relative roles of NH2 and NH4 vary in different cell lines and have not been examined in nonimmortalized cells. Here, we have used a series of differentiation, proliferation,...
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