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Article

Human P2X7 pore function predicts allele linkage disequilibrium.

Clinical chemistry - 1 Jun 2006

Denlinger Loren C, Coursin Douglas B, Schell Kathleen, Angelini Giuditta, Green Dawn N, Guadarrama Arturo G, Halsey Jennifer, Prabhu Usha, Hogan Kirk J, Bertics Paul J

Abstract excerpt

BACKGROUND: Innate immune response amplification is achieved by leukocyte expression of the purinergic nucleotide receptor P2X7, an extracellular nucleotide-gated pore. Previously, low P2X7 pore activity in whole blood was associated with loss-of-function genotypes in correlation with a decreased ratio of lipopolysaccharide-stimulated tumor necrosis factor-alpha to interleukin-10, of relevance to a variety of...

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Identifiers

PMID: 16613995
DOI: 10.1373/clinchem.2005.065425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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