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Article

Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia.

Lancet (London, England) - 14 Dec 2002

Thunberg Ulf, Tobin Gerard, Johnson Anna, Söderberg Ola, Padyukov Leonid, Hultdin Magnus, Klareskog Lars, Enblad Gunilla, Sundström Christer, Roos Göran, Rosenquist Richard

Abstract excerpt

BACKGROUND: The P2X7 receptor is a ligand-gated cation channel that mediates ATP-induced apoptotic death in haemopoietic and chronic lymphocytic leukaemia (CLL) cells. We aimed to investigate the clinical effect of a single nucleotide polymorphism in the P2X7 receptor gene (1513A-->C) and correlate findings with the immunoglobulin heavy chain variable (V(H)) gene mutation status, a prognostic marker in CLL....

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Identifiers

PMID: 12493261
DOI: 10.1016/S0140-6736(02)11917-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia.PMID 12493261Read ↗

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