Article
Bone marrow stem cell therapy partially ameliorates pathological consequences in livers of mice expressing mutant human α1-antitrypsin.
Hepatology (Baltimore, Md.) - 1 Apr 2017
Baligar Prakash, Kochat Veena, Arindkar Shailendra K, Equbal Zaffar, Mukherjee Snehashish, Patel Swati, Nagarajan Perumal, Mohanty Sujata, Teckman Jeffrey H, Mukhopadhyay Asok
Abstract excerpt
Alpha-1-antitrypsin (AAT) deficiency (AATD) is a genetic disease, caused by mutation of the AAT gene. Accumulation of mutated AAT protein aggregates in hepatocytes leads to endoplasmic reticulum stress, resulting in impairment of liver functions and, in some cases, hepatocellular carcinoma, whereas decline of AAT levels in sera is responsible for pulmonary emphysema. In advanced liver disease, the only option for...
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