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Article

Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation.

FEBS letters - 1 May 2007

Inoue Shin-Ichi, Yokota Mutsumi, Nakada Kazuto, Miyoshi Hiroyuki, Hayashi Jun-Ichi

Abstract excerpt

Anemia is a symptom in patients with Pearson syndrome caused by the accumulation of mutated mitochondrial DNA (mtDNA). Such mutated mtDNAs have been detected in patients with anemia. This suggested that respiration defects due to mutated mtDNA are responsible for the anemia. However, there has been no convincing experimental evidence to confirm the pathophysiological relation between respiration defects in...

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Identifiers

PMID: 17434485
DOI: 10.1016/j.febslet.2007.03.092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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