Article
Susceptibility of a herpes simplex virus ribonucleotide reductase null mutant to deoxyribonucleosides and antiviral nucleoside analogs.
Microbiology and immunology - 1 Jan 1991
Yamada Y, Yamamoto N, Daikoku T, Nishiyama Y
Abstract excerpt
A herpes simplex virus ribonucleotide reductase (RR) null mutant, ICP6 delta, exhibited hypersensitivity to hydroxyurea, and to the precursors of allosteric inhibitors of cellular RR. The mutant was also much more sensitive than the parental KOS to all of antiviral nucleoside analogs tested, including acyclovir (ACV), ganciclovir (DHPG) and BVaraU. Our data indicate that cellular RR is essential for the growth of...
Topics
- Acyclovir
- Arabinofuranosyluracil
- Deoxyribonucleosides
- Ganciclovir
- Hydroxyurea
- Mutation
- Nucleic Acid Synthesis Inhibitors
- Ribonucleotide Reductases
- Simplexvirus