Article
Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2006
Beekman Marian, Blauw Gerard Jan, Houwing-Duistermaat Jeanine J, Brandt Bernd W, Westendorp Rudi G J, Slagboom P Eline
Abstract excerpt
Recently, chromosome 4q25 was linked to exceptional human longevity, and a haplotype of the positional candidate microsomal transfer protein (MTP) gene was associated to the phenotype in U.S. Caucasians. We investigated whether linkage to 4q25 could be detected in 164 nonagenarian sibships of the Leiden Longevity Study. Additionally, we compared the MTP -493G/T and Q95H allele and haplotype frequencies in the...
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