Article
Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2006
Révillion Françoise, Charlier Madia, Lhotellier Valérie, Hornez Louis, Giard Sylvia, Baranzelli Marie-Christine, Djiane Jean, Peyrat Jean-Philippe
Abstract excerpt
PURPOSE: Leptin and obesity are clearly related, and obesity is associated with an increased risk of breast cancer. We therefore measured the expression of leptin and its two main receptor isoforms, OBR-L and OBR-S, in 322 breast cancers. We analyzed their relations with the classical prognostic factors and with survival to establish their links with breast cancer. EXPERIMENTAL DESIGN: The expression of leptin...
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