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Biochemical study on modifying role of variants of leptin gene and its receptor on serum leptin levels in breast cancer.

Molecular biology reports - 1 May 2020

Tayel Safaa I, Alhanafy Alshimaa M, Ahmed Solwan M, Eltorgoman Abdelmoneim A, Elsayed Ibrahim E

Abstract excerpt

The leptin is discharged from breast adipose tissue and is overexpressed in breast cancer (BC). Conflicting relation of leptin with BC was reported. We investigated this association and its impact on leptin level and disease characteristics. The study included 70 females (40 women with pathological proof of invasive BC patients and 30 controls). LEP and LEPR polymorphisms were evaluated by real-time PCR. Serum...

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PMID: 32279213
DOI: 10.1007/s11033-020-05436-0

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