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Article

Obesity impacts the regulation of miR-10b and its targets in primary breast tumors

18 Jan 2019

Abstract excerpt

BACKGROUND: Obesity increases breast cancer (BC) risk in post-menopausal women by mostly unknown molecular mechanisms which may partly be regulated by microRNAs (miRNAs). METHODS: We isolated RNA from paired benign and malignant biopsies from 83 BC patients and determined miRNA profiles in samples from 12 women at the extremes of the BMI distribution by RNA-seq. Candidates were validated in all samples....

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PMID: 30658617
DOI: 10.1186/s12885-019-5300-6

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