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Article

Organophosphate Hydrolysis by a Designed Metalloenzyme: Impact of Mutations Explained.

The journal of physical chemistry. B - 19 Dec 2024

Dyguda-Kazimierowicz Edyta, Jedwabny Wiktoria

Abstract excerpt

The efficient design of novel enzymes has been attainable only by a combination of theoretical approaches and experimental refinement, suggesting inadequate performance of de novo design protocols. Based on the analysis of the evolutionary trajectory of a designed organophosphate hydrolase, this work aimed at developing and validating the improved theoretical models describing the catalytic activity of five...

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PMID: 39648809
DOI: 10.1021/acs.jpcb.4c06809

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