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Article

Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius.

Proteins - 1 Jun 2008

Mandrich Luigi, Menchise Valeria, Alterio Vincenzo, De Simone Giuseppina, Pedone Carlo, Rossi Mosè, Manco Giuseppe

Abstract excerpt

Recent mutagenic and molecular modelling studies suggested a role for glycine 84 in the putative oxyanion loop of the carboxylesterase EST2 from Alicyclobacillus acidocaldarius. A 114 times decrease of the esterase catalytic activity of the G84S mutant was observed, without changes in the thermal...

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PMID: 18076040
DOI: 10.1002/prot.21877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18076040-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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